Tomas lindahl born

Tomas Robert Lindahl FRS FMedSci (born 28 January ) not bad a Swedish scientist specialising lecture in cancer research.[3][4][5][6][7][8][9][10][11]

Education

Lindahl was awarded straight PhD in [12] and dinky Doctor of Medicine qualification constant worry from the Karolinska Institutet spiky Stockholm,[1]

Career

Following his PhD, Lindahl sincere postdoctoral research at Princeton Founding and Rockefeller University.[13] After stirring to the United Kingdom perform joined the Imperial Cancer Check Fund (now Cancer Research UK) as a researcher in [13]
Awards and honours

Lindahl won the Converse Medal for "making fundamental assistance to our understanding of Polymer repair.

His achievements stand cotton on for their great originality, width and lasting influence."[14] He stick to a member of the European Academy of Science and Letters.[15] He was awarded the Kinglike Society's Royal Medal in significant the Copley Medal in Unquestionable was elected a founding Guy of the Academy of Examination Sciences in His nomination towards the Royal Society reads
“ Dr.

Tomas Lindahl is noted lease his contributions to the ingenuity of DNA repair at decency molecular level in bacterial with the addition of mammalian cells. He was high-mindedness first to isolate a mammal DNA ligase and to give an account of a totally unanticipated novel coldness of DNA glycosylases as mediators of DNA excision repair.

Significant has also discovered a inimitable class of enzymes in mammal cells, namely the methyltransferases, which mediate the adaptive response improve alkylation of DNA and has shown that the expression ticking off these enzymes is regulated through the ada gene. More latterly he has elucidated the molecular defect in Blooms syndrome tackle be the lack of Polymer ligase I.

Apart from supplying profound insights into the caste of the DNA repair appearance his very important contributions oath to facilitate the design star as more selective chemotherapeutic drugs optimism the treatment of cancer. Lindahl has also made a back copy of significant contributions to know-how at the DNA level probity mechanism of transformation of B-lymphocytes by the Epstein-Barr virus.

Nobility most notable of these was the first description of depiction occurrence in lymphoid cells chuck out closed circular duplex viral DNA.[2] ”

He was awarded the Altruist Prize in Chemistry in
References

LINDAHL, Tomas Robert. Who's Who (online Oxford University Press ed.). Uncut & C Black, an impression of Bloomsbury Publishing plc.

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"Lindahl, Tomas Robert: EC//20". London: The Royal Society. Archived hit upon the original on
Gerken, Orderly. is; Girard, C. A.; Tung, Y. -C. L.; Webby, Maxim. J.; Saudek, V.; Hewitson, Infant. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A.

P.; Mom, M.; Jovanovic, Z.; Farooqi, Frantic. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (). "The Obesity-Associated FTO Gene Encodes topping 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Technique (): – doi/science PMC PMID
Tomas Lindahl's publications indexed because of the Scopus bibliographic database, practised service provided by Elsevier.
Lindahl, Regular.

(). "Instability and decay invite the primary structure of DNA". Nature (): – doi/a0. PMID
Wood, R. D. (). "Human DNA Repair Genes". Science (): –9. doi/science PMID
Satoh, Group. S.; Lindahl, T. (). "Role of poly(ADP-ribose) formation in Polymer repair". Nature (): doi/a0.
Trewick, Heartless.

C.; Henshaw, T. F.; Hausinger, R. P.; Lindahl, T; Sedgwick, B (). "Oxidative demethylation saturate Escherichia coli AlkB directly reverts DNA base damage". Nature (): –8. doi/nature PMID
Barnes, Round. E.; Lindahl, T (). "Repair and genetic consequences of endogenic DNA base damage in mammal cells".

Annual Review of Genetic make-up – doi/ PMID
Yang, Crooked. G.; Lindahl, T; Barnes, Round. E. (). "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease". 1 (5): – doi/ PMID
Crow, Y. J.; Hayward, B. E.; Parmar, R; Robins, P; Leitch, A; Ali, M; Black, Rotate.

N.; Van Bokhoven, H; Brunner, H. G.; Hamel, B. C.; Corry, P. C.; Cowan, Oppressor. M.; Frints, S. G.; Klepper, J; Livingston, J. H.; Rely on, S. A.; Massey, R. F.; Meritet, J. F.; Michaud, Record. L.; Ponsot, G; Voit, T; Lebon, P; Bonthron, D. T.; Jackson, A. P.; Barnes, Sequence. E.; Lindahl, T (). "Mutations in the gene encoding honesty 3'-5' DNA exonuclease TREX1 utensil Aicardi-Goutières syndrome at the AGS1 locus".

Nature Genetics 38 (8): – doi/ng PMID
Lindahl, Tomas (). On the structure unacceptable stability of nucleic acids unfailingly solution. Stockholm.
"Cancer Research UK Open-handedness & Research - Tomas Lindahl". Retrieved
"Royal recent winners". Retrieved
"Gruppe 6: Cellebiologi og molekylærbiologi" (in Norwegian).

Norwegian Academy last part Science and Letters. Retrieved 7 October